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What Is Olanzapine and How Does It Work?

Potential consequences of weight gain should be considered prior to starting olanzapine. Olanzapine did not influence the pharmacokinetics of diazepam or its active metabolite N-desmethyldiazepam. Peel blister pouch and remove device. Because olanzapine is highly metabolized before excretion and only 7% of the drug is excreted unchanged, renal dysfunction alone is unlikely to have a major impact on the pharmacokinetics of olanzapine. The pharmacokinetic characteristics of olanzapine were similar in patients with severe renal impairment and normal subjects, indicating that dosage adjustment based upon the degree of renal impairment is not required. In addition, olanzapine is not removed by dialysis. The effect of renal impairment on metabolite elimination has not been studied.

Therapeutic Research Faculty 2009

Where can I get more information? During premarketing clinical studies, reactions that presented with signs and symptoms consistent with olanzapine overdose have been reported in patients following an injection of Zyprexa Relprevv. It is mandatory that patients be enrolled in the Zyprexa Relprevv Patient Care Program to receive Zyprexa Relprevv treatment. Establish tolerability with oral olanzapine prior to initiating treatment. Weight gain. Weight gain is very common in people who take Zyprexa. Teenagers 13 to 17 years old are more likely to gain weight and to gain more weight than adults. Children 10 to 17 years old are also more likely to gain weight and to gain more weight than adults when Zyprexa is used in combination with fluoxetine. Some people may gain a lot of weight while taking Zyprexa, so you and your doctor should check your weight regularly. Talk to your doctor about ways to control weight gain, such as eating a healthy, balanced diet, and exercising.

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Olanzapine can cause high blood sugar hyperglycemia. If you are diabetic, check your blood sugar levels on a regular basis while you are taking olanzapine. For specific information about the contraindications of lithium or valproate, refer to the Contraindications section of the package inserts for these other products. Comparison of Zyprexa Relprevv and oral olanzapine, in a 24 week study, revealed no significant differences on ECG changes.

Zyprexa overdose

For specific information about the adverse reactions observed with lithium or valproate, refer to the Adverse Reactions section of the package inserts for these other products. If signs and symptoms of tardive dyskinesia appear in a patient on olanzapine, drug discontinuation should be considered. However, some patients may require treatment with olanzapine despite the presence of the syndrome. For deep intramuscular gluteal injection only. Not to be injected intravenously or subcutaneously. Olanzapine displays linear kinetics over the clinical dosing range.

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Patients should be counseled that weight gain has occurred during treatment with Zyprexa. The drug product is olanzapine pamoate monohydrate, present as a yellow solid in a glass vial equivalent to 210, 300, or 405 mg olanzapine base per vial. In a study of patients who were already tolerating either lithium or valproate as monotherapy, discontinuation rates due to adverse reactions were 11% for the combination of oral olanzapine with lithium or valproate compared to 2% for patients who remained on lithium or valproate monotherapy. Discontinuations with the combination of oral olanzapine and lithium or valproate that occurred in more than 1 patient were: somnolence 3% weight gain 1% and peripheral edema 1%. If you currently have, or have had any problems in the past with addictive drugs, including street drugs and medication, you should talk with your doctor before you take this medication. You should also mention any serious reactions you may have had to other similar medications. If you are taking other prescription drugs or supplements, you should check with your doctor or pharmacist before taking this drug. The information contained in the Truven Health Micromedex products as delivered by Drugs. Problems with control of body temperature: You could become very hot, for instance when you exercise a lot or stay in an area that is very hot. It is important for you to drink water to avoid dehydration. If you miss a dose of Zyprexa Intramuscular, contact your doctor right away.

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The tablet will disintegrate quickly in your saliva so that you can easily swallow it with or without drinking liquid. The drug product is suspended in the diluent for Zyprexa Relprevv to a target concentration of 150 mg olanzapine per mL prior to intramuscular injection. These terms represent serious adverse events but do not meet the definition for adverse drug reactions. They are included here because of their seriousness. Examination of population subsets race and gender did not reveal any differential responsiveness on the basis of these subgroupings. Keep Zyprexa away from light. The term abdominal pain upper was combined under abdominal pain. People who take this drug may experience fainting if they stand up too quickly from a lying or sitting position. This is a condition known as orthostatic hypotension and is a common side effect among antipsychotic medications. To reduce the possibility of injury, put both feet on the floor and stand up slowly. Zyprexa is usually taken by mouth as tablets, but the injection can be used for the rapid control of agitation or disturbed behaviour in adults with schizophrenia or a manic episode, when taking the medicine by mouth is not appropriate. Call your doctor if you do not think you are getting better or have any concerns about your condition while taking Zyprexa Relprevv. hydroxychloroquine

Eli Lilly and Company

Co-administration of lorazepam does not significantly affect the pharmacokinetics of olanzapine, unconjugated lorazepam, or total lorazepam. However, this co-administration of lorazepam with olanzapine potentiated the somnolence observed with either drug alone. Zyprexa ZYDIS olanzapine orally disintegrating tablets is intended for oral administration only. There are no systematically collected data to specifically address how to switch patients with schizophrenia from other antipsychotics to Zyprexa Relprevv. Use Zyprexa Intramuscular as directed by your doctor. Check the label on the medicine for exact dosing instructions. ALT, AST, and GGT. Dose group differences with respect to increases in fasting triglycerides have been observed. In a 24-week randomized, double-blind, fixed-dose study with Zyprexa Relprevv, statistically significant differences among dose groups have been observed for fasting triglycerides. III-R criteria for schizophrenia. A single haloperidol arm was included as a comparative treatment in 1 of the 2 trials, but this trial did not compare these 2 drugs on the full range of clinically relevant doses for both. order doxazosin from boots doxazosin

Zyprexa ingredients

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the medication guide if you do not have one. Placental transfer of olanzapine occurs in rat pups. Single doses of olanzapine did not affect the pharmacokinetics of imipramine or its active metabolite desipramine. The studies also showed an increased risk of among elderly patients with dementia using Zyprexa. Prescribing information for the drug was updated in January 2004 to include information on this risk. Patients and caregivers should be counseled that a potentially fatal symptom complex sometimes referred to as NMS has been reported in association with administration of antipsychotic drugs, including Zyprexa. In placebo-controlled trials, there was a significantly higher incidence of cerebrovascular adverse events in patients treated with oral olanzapine compared to patients treated with placebo. They are negative voices that tell me "you're ugly, you're fat, you're unattractive, nobody wants you, you should disappear, etc. Attach the new safety needle to the syringe prior to injection. Once the suspension has been removed from the vial, it should be injected immediately. What are some ways to get the most out of my treatment with this medication? The following table addresses dose relatedness for other adverse reactions using data from a schizophrenia trial involving fixed dosage ranges of oral olanzapine. It enumerates the percentage of patients with treatment-emergent adverse reactions for the 3 fixed-dose range groups and placebo. The data were analyzed using the Cochran-Armitage test, excluding the placebo group, and the table includes only those adverse reactions for which there was a trend. What are the ingredients in Zyprexa Relprevv? What should I do if I overdose on this medication? No oral antipsychotic supplementation was allowed throughout the trial. The primary efficacy measure was time to exacerbation of symptoms of schizophrenia defined in terms of increases in Brief Psychiatric Rating Scale BPRS positive symptoms or hospitalization. This medicine may increase your cholesterol and fats in the blood. If this condition occurs, your doctor may give you or your child some medicines that can lower the amount of cholesterol and fats in the blood.

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Some medical conditions may interact with Zyprexa Intramuscular. The following table enumerates the percentage of patients with treatment-emergent extrapyramidal symptoms as assessed by categorical analyses of formal rating scales during acute therapy in a controlled clinical trial comparing oral olanzapine at 3 fixed doses with placebo in the treatment of schizophrenia in a 6-week trial. The terms alanine aminotransferase ALT aspartate aminotransferase AST and hepatic enzyme were combined under liver enzymes. The term sinus congestion was combined under nasal congestion. There are no adequate and well-controlled trials with olanzapine in pregnant females. Four pregnancies were observed during clinical trials with Zyprexa Relprevv, including 1 resulting in a normal birth and 3 therapeutic abortions. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. High blood sugar or diabetes, high cholesterol, and weight gain have happened with medicines like this one. These changes may increase the risk of heart and brain blood vessel disease. Discuss any questions or concerns with your doctor. Patent and Trademark Office and certain other countries. Dosage adjustments, if indicated, should generally occur at intervals of not less than 24 hours, reflecting the procedures in the placebo-controlled trials. When using Zyprexa and fluoxetine in combination, also refer to the Boxed Warning section of the package insert for Symbyax. There are 2 types of injection short- and long-acting. These 2 forms have different uses and dosing and the 2 products are not interchangeable. Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor. Constipation; dizziness; drowsiness; dry mouth; light-headedness; pain, redness, or swelling at the injection site; weakness; weight gain. Zyprexa available in form. Common side effects of Zyprexa Relprevv include: headache, sleepiness or drowsiness, weight gain, dry mouth, diarrhea, nausea, common cold, eating more increased appetite vomiting, cough, back pain, or pain at the injection site. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. toradol roche price toradol

How should I receive Zyprexa Relprevv?

None of these patients experienced jaundice. In 3 of these patients, liver enzymes reverted to the normal range despite continued treatment, and in 5 cases enzymes values decreased, but were still above the normal range at the end of therapy. Alzheimer's dementia. Olanzapine is not approved for the treatment of patients with Alzheimer's disease. Conditions that lower the seizure threshold may be more prevalent in a population of 65 years or older. AUC for total radioactivity, indicating significant exposure to metabolites. The presence of other medical problems may affect the use of this medicine. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. If you have diabetes, follow your doctor's instructions about how often to check your blood sugar while taking Zyprexa. Zyprexa may not be right for you. If any of these effects persist or worsen, tell your doctor or promptly. NMS has been reported in association with administration of antipsychotic drugs, including olanzapine. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmia. Additional signs may include elevated creatinine phosphokinase, myoglobinuria rhabdomyolysis and acute renal failure. Olanzapine clearance is about 40% higher in smokers than in nonsmokers, although dosage modifications are not routinely recommended. Olanzapine exhibits in vitro muscarinic receptor affinity. In premarketing clinical trials with oral olanzapine, olanzapine was associated with constipation, dry mouth, and tachycardia, all adverse reactions possibly related to cholinergic antagonism. Such adverse reactions were not often the basis for discontinuations from olanzapine, but olanzapine should be used with caution in patients with clinically significant prostatic hypertrophy, narrow angle glaucoma, or a history of paralytic ileus or related conditions. In postmarketing reports of overdose with olanzapine alone, symptoms have been reported in the majority of cases. The following table enumerates the percentage of patients with treatment-emergent extrapyramidal symptoms as assessed by categorical analyses of formal rating scales during controlled clinical trials comparing fixed doses of intramuscular olanzapine for injection with placebo in agitation. Take Zyprexa exactly as prescribed. Your doctor may need to change adjust the dose of Zyprexa until it is right for you. Zyprexa Relprevv and have their WBC followed until recovery. can i buy gemfibrozil in spain

Frequent: injection site pain

ZYPREXA monotherapy is not indicated for treatment of treatment resistant depression major depressive disorder in patients who do not respond to 2 antidepressants of adequate dose and duration in the current episode. The risk of developing tardive dyskinesia and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase. However, the syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses or may even arise after discontinuation of treatment. Olanzapine's specific metabolic profile is presented below. The possibility of multiple drug involvement should be considered. In case of acute overdosage, establish and maintain an airway and ensure adequate oxygenation and ventilation, which may include intubation. Gastric lavage after intubation, if patient is unconscious and administration of activated charcoal together with a laxative should be considered. At first, 10 to 15 milligrams mg once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day. It may also be used in combination with other medication to treat depression. This medication can help to decrease and help you to think more clearly and positively about yourself, feel less agitated, and take a more active part in everyday life. Mean increase in weight in adolescents was greater than in adults. In 4 placebo-controlled trials, discontinuation due to weight gain occurred in 1% of olanzapine-treated patients, compared to 0% of placebo-treated patients. When using Zyprexa and fluoxetine in combination, refer to the Clinical Studies section of the package insert for Symbyax. Khan, I. A. Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. J Nat. Avoid using alcohol with this medication. Alcohol may increase the intensity and frequency of side effects. Keep out of the reach of children. Patients taking olanzapine should be monitored regularly for worsening of glucose control. Patients starting treatment with olanzapine should undergo fasting blood glucose testing at the beginning of treatment and periodically during treatment. Any patient treated with atypical antipsychotics should be monitored for symptoms of hyperglycemia including polydipsia, polyuria, polyphagia, and weakness. Patients who develop symptoms of hyperglycemia during treatment with atypical antipsychotics should undergo fasting blood glucose testing.

Zyprexa uses

Increased incidence of stroke or “mini-strokes” called transient ischemic attacks TIAs in elderly people with dementia-related psychosis elderly people who have lost touch with reality due to confusion and memory loss. Zyprexa is not approved for these patients. Zyprexa may cause somnolence, postural hypotension, motor and sensory instability, which may lead to falls and, consequently, fractures or other injuries. For patients with diseases, conditions, or medications that could exacerbate these effects, complete fall risk assessments when initiating antipsychotic treatment and recurrently for patients on long-term antipsychotic therapy. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Infrequent: creatine phosphokinase increased. Zyprexa Relprevv is intended for deep intramuscular gluteal injection only and should not be administered intravenously or subcutaneously. Precautions noted below need to be carefully weighed. buy flonase kuwait

Reviews for zyprexa

Statistically significant within group mean changes for Zyprexa Relprevv, which were also significantly different from oral olanzapine in a 24-week double-blind study were observed for the following: gamma-glutamyltransferase GGT and sodium. Protect Zyprexa tablets and Zyprexa ZYDIS from light and moisture. Protect Zyprexa IntraMuscular from light, do not freeze. FOR DEEP INTRAMUSCULAR GLUTEAL INJECTION ONLY. The pharmacokinetic characteristics of orally administered olanzapine were similar in patients with severe renal impairment and normal subjects, indicating that dosage adjustment based upon the degree of renal impairment is not required. In addition, olanzapine is not removed by dialysis. The effect of renal impairment on metabolite elimination has not been studied. HCl is a fixed-dose combination of ZYPREXA and fluoxetine. Zyprexa is usually taken one time each day. In pooled studies of adults as well as pooled studies of adolescents, there were no significant differences between olanzapine and placebo in the proportions of patients experiencing potentially important changes in ECG parameters, including QT, QTc Fridericia corrected and PR intervals. In clinical studies, changes in prolactin levels were found to be statistically significantly different based on dose, higher doses were associated with higher levels of prolactin. In a study of up to 12 weeks, plasma prolactin concentrations exceeded the upper limit of normal ULN in approximately 30% of patients who had normal baseline prolactin values. The majority of these elevations were mild, and remained below 2 x ULN. karge.info cephalexin

What should I do if I miss a dose?

This listing is not intended to include reactions 1 already listed in previous tables or elsewhere in labeling, 2 for which a drug cause was remote, 3 which were so general as to be uninformative, 4 which were not considered to have significant clinical implications, or 5 which occurred at a rate equal to or less than placebo. This drug may cause significant weight gain and a rise in your or levels, especially in teenagers. Food and Drug Administration. The prescriber should be aware that the figures in the tables and tabulations cannot be used to predict the incidence of side effects in the course of usual medical practice where patient characteristics and other factors differ from those that prevailed in the clinical trials. Similarly, the cited frequencies cannot be compared with figures obtained from other clinical investigations involving different treatments, uses, and investigators. The cited figures, however, do provide the prescribing physician with some basis for estimating the relative contribution of drug and nondrug factors to the adverse reaction incidence in the population studied. Dose group differences with respect to weight gain have been observed in some studies. Olanzapine is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder manic depression in adults and children who are at least 13 years old. This medicine may cause a condition called drug reaction with eosinophilia and systemic symptoms DRESS. Call your doctor right away if you have a rash, red, swollen skin, fever, chills, cough, trouble breathing, swollen glands, or unusual bleeding, bruising, or weakness after using this medicine. Keep Zyprexa and all medicines out of the reach of children.

Do not use with Paraldehyde

It has not been approved for treating dementia-related mental problems among the elderly. After use, place sharps in a suitable sharps container. In clinical trials of oral olanzapine monotherapy for the treatment of schizophrenia in adult patients, treatment-emergent adverse reactions with an incidence of 5% or greater in the olanzapine treatment arm and at least twice that of placebo were: postural hypotension, constipation, weight gain, dizziness, personality disorder, and akathisia. Zyprexa Relprevv can pass into your breast milk and may harm your baby. You should not breast-feed while taking Zyprexa Relprevv. Talk to your doctor about the best way to feed your baby if you take Zyprexa Relprevv. Patients with the following COSTART terms were counted in this category: dystonia, generalized spasm, neck rigidity, oculogyric crisis, opisthotonos, torticollis. In general, the decision to use Zyprexa Relprevv in specific populations should be thoughtfully considered. For patients who have never taken oral olanzapine, tolerability should be established with oral olanzapine prior to initiating treatment with Zyprexa Relprevv. Neither clinical studies nor epidemiologic studies conducted to date have shown an association between chronic administration of this class of drugs and tumorigenesis in humans; the available evidence is considered too limited to be conclusive at this time. Efficacy was established in three clinical trials in adult patients with manic or mixed episodes of bipolar I disorder: two 3- to 4-week trials and one monotherapy maintenance trial. imipramine

Zyprexa dosing information

Some patients who take Zyprexa Intramuscular may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Zyprexa Intramuscular in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw eg, chewing movements, mouth puckering, puffing of cheeks, tongue sticking out while taking Zyprexa Intramuscular. Caution should be exercised in patients with signs and symptoms of hepatic impairment, in patients with pre-existing conditions associated with limited hepatic functional reserve, and in patients who are being treated with potentially hepatotoxic drugs. Some patients have experienced weight gain while using Zyprexa Intramuscular. You may need to have regular weight checks while you use Zyprexa Intramuscular. Increased risk of death in elderly people who are confused, have memory loss and have lost touch with reality dementia-related psychosis. Zyprexa is not approved for treating psychosis in elderly people with dementia. LILLY and tablet number. Overall, there was no difference in the incidence of discontinuation due to adverse reactions 5% for oral olanzapine vs 6% for placebo. However, discontinuations due to increases in ALT were considered to be drug related 2% for oral olanzapine vs 0% for placebo. Avoid becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking olanzapine. Medline Plus. 2013. Olanzapine. The central dopaminergic blocking effects of neuroleptic agents may precipitate or aggravate a potentially fatal symptom complex known as neuroleptic malignant syndrome NMS. NMS is observed most frequently when high-potency agents like haloperidol are administered intramuscularly, but may occur with any neuroleptic agent given for any length of time. Clinical manifestations of NMS include hyperpyrexia, muscle rigidity, altered mental status and autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac arrhythmias. Additional signs may include elevated creatine phosphokinase, myoglobinuria, and acute renal failure. Neuroleptic agents should not be given to patients with active NMS and should be immediately discontinued if currently being administered in such patients. In patients with a history of NMS, introduction or reintroduction of neuroleptic agents should be carefully considered, since NMS may recur. desyrel

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Does zyprexa interact with other medications

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Given these considerations, olanzapine should be prescribed in a manner that is most likely to minimize the occurrence of tardive dyskinesia. Zyprexa Relprevv treatment. Your doctor will talk to you about the risks and benefits of Zyprexa Relprevv treatment. If you have diabetes, follow your doctor's instructions about how often to check your blood sugar while taking Zyprexa Relprevv. Visually confirm that the needle is fully engaged into the needle protection sheath. lowest price for luvox

What is Zyprexa used for?

Oral olanzapine should be administered in combination with fluoxetine once daily in the evening, without regard to meals, generally beginning with 5 mg of oral olanzapine and 20 mg of fluoxetine. The possibility of obtundation, seizures, or dystonic reaction of the head and neck following overdose may create a risk of aspiration with induced emesis. Cardiovascular monitoring should commence immediately and should include continuous electrocardiographic monitoring to detect possible arrhythmias. These requirements apply in the United States. If you live in Canada or any other country, consult your doctor and pharmacist for your country's regulations.

Zyprexa consumer information

All doses were statistically superior to placebo on the PANSS Excited Component at 2 hours post-injection. However, the effect was larger and more consistent for the 3 highest doses. Tell your doctor about all the medicines that you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Zyprexa Relprevv and some medicines may interact with each other and may not work as well, or cause possible serious side effects. Your doctor can tell you if it is safe to take Zyprexa Relprevv with your other medicines. Do not start or stop any medicine while taking Zyprexa Relprevv without talking to your doctor first. buy arcoxia rezeptfrei

Zyprexa warnings

Omeprazole and rifampin may cause an increase in olanzapine clearance. Some teens who take this medication report weight gain, high levels of fat in the blood, liver problems, breast enlargement, and breast discharge. For best results, teens taking Zyprexa should consider using this medication as part of an overall treatment plan that includes therapy. Teens are more likely to experience side effects from this medication than adults. Open the sachet and peel back the foil on the blister. Do not push the tablet through the foil. Eli Lilly and Company has received reports of fatality in association with overdose of oral olanzapine alone.

Hyperprolactinemia may suppress hypothalamic GnRH, resulting in reduced pituitary gonadotropin secretion. This, in turn, may inhibit reproductive function by impairing gonadal steroidogenesis in both female and male patients. Galactorrhea, amenorrhea, gynecomastia, and impotence have been reported in patients receiving prolactin-elevating compounds. Long-standing hyperprolactinemia when associated with hypogonadism may lead to decreased bone density in both female and male subjects. Olanzapine is indicated for the treatment of schizophrenia. The combined effects of age, smoking, and gender could lead to substantial pharmacokinetic differences in populations. The clearance in young smoking males, for example, may be 3 times higher than that in elderly nonsmoking females. quinine

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